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Effect of the External Electric Field on the Structure and Reactivity of Model Complex Lipids

[ Vol. 7 , Issue. 1 ]

Author(s):

Jozef Mazurkiewicz, Henryk Koloczek and Piotr Tomasik   Pages 71 - 80 ( 10 )

Abstract:


Background: The study of the effect of external electric field on the structure and reactivity of fatty acids and their glycerides is now extended to selected derived lipids.

Objectives: The present study involves computations of changes in energy and dipole moments, charge density and bond lengths of β-carotene (a carotenoid), cholesterol (a sterol), sphingosine and ceramide (sphingolipids) and phosphatidylcholine (a phospholipid) in the external electric field of 0.00, 5.14, 25.70 and 51.40 MV/cm.

Method: The computations were performed applying HyperChem 8.0 software together with the PM3 method for optimization of the conformation of the molecules.

Results: The raise in the EEF strength to 5.14 MV/cm has a subtle effect on the molecular energy of the lipids under study. A slight tendency in decreasing that energy can, however, be observed. On elevating the strength up to 25.70 MV/cm that decrease in molecular energy was more significant.

Conclusions: Observed changes evoked by the EEF were specific for particular molecules. They resulted mainly from the polarization of the bonds and to a lesser extent from steric deformations of the molecules.

Keywords:

β-carotene, ceramide, cholesterole, phosphatidylcholine sphingosine, polarization, lipids.

Affiliation:

Department of Chemistry and Physics, University of Agriculture, Krakow, Department of Inorganic Technology and Environmental Biotechnology, Cracow University of Technology,, 30155 Krakow, Krakow College of Health Promotion, Krowoderska Street, 73, 31158 Krakow

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